Scientists develop indigenous nasopharyngeal swabs

Swab for collecting samples of Covid-19 patients

Photo - Bioworld Medtech via internet

In the current pandemic scenario, global supplies of nasopharyngeal (NP) swabs are not dependable, resulting in supply chain delays, escalating prices and variable quality. CSIR-National Chemical Laboratory (CSIR-NCL), Pune, has developed an indigenous NP swab for collecting samples from the throat cavity of Covid-19 patients. CSIR flagged the need for making available domestic technology for NP swabs to NCL in mid-April.

The nasopharyngeal swab is a medical device with stringent specifications of quality, polymer grade, dimensions and sterilization. An NP swab consists of a cylindrical plastic stick with a brush-like tip of synthetic bristles or flocks. The flocking process helps align the fine bristles in a parallel orientation on the stick head, much like a toothbrush, except that this has round uniform geometry and the NP swab bristles are of a micron diameter.

Indigenous NP swab for collecting samples from the throat cavity of Covid-19 patients

The NCL team of polymer science and chemical engineering scientists – which included Chandrashekhar V Rode, Prakash P Wadgaonkar, and Anuya A Nisal – successfully worked out the detailed specifications of NP swab polymers and adhesives. The specifications included medical-grade materials that must be used for manufacture, the swab design and the packaging and sterilization protocols. “This is an excellent example of optimizing the polymer specifications and validating the chemical analysis of an urgently needed medical swab product in a short time,” noted Ashwini Kumar Nangia, director, NCL.

The NCL has transferred the process knowhow of indigenous NP swabs for sample collection to a Mumbai-based chemical company under the Covid-19 technology transfer guidelines of CSIR. After confirming the correct chemical and polymer composition of NP swabs, their diameter, alignment of bristles, and sterilization method, NCL has suggested the next regulatory pathway for approval of medical devices to the company. According to NCL, they will be able to produce 1 lakh NP swabs in a day.


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