Merck, a leading science and technology company, announced that the United States Patent and Trademark Office has granted the company’s patent for CRISPR-chromatin technology. With this allowance, Merck is the only provider with a patent covering the fusion of chromatin modulating peptides to CRISPR proteins, helping to clear chromatin out of the way, increasing access to the genome.
“This award marks our second US CRISPR patent and our 23rd CRISPR-related patent worldwide. As a leading innovator of CRISPR technology, we will continue to drive innovation and collaborate with scientists around the world to ensure that they have the most advanced gene-editing options,” said Udit Batra, member of the Merck Executive Board and chief executive officer of Life Science.
Because genomic DNA in mammalian cells is wrapped tightly in protein complexes called chromatin, the genomic DNA is often inaccessible to CRISPR. Merck’s CRISPR-chrom technology works by fusing chromatin modulating peptides to a CRISPR protein, Cas9 (that is CRISPR’s DNA scissors), allowing for more efficient gene editing. This work was initially published in the February 2018 issue of The CRISPR Journal and was one of the journal’s top five downloaded articles of the year. The Life Science business of Merck, a leader in genome editing, conducts research and development to drive improvements in gene-editing technologies.
Merck’s CRISPR patent portfolio includes granted patents for CRISPR-related technologies covering foundational and alternative genome-editing methods. Patents for the company’s CRISPR integration technology have been granted in Australia, Canada, China, Europe, Israel, Singapore, and South Korea. Patents granted in Europe and pending elsewhere cover plasmid or viral vectors encoding CRISPR systems, which are necessary to perform genome modification in eukaryotic cells. Other European patents and pending applications are for protein-RNA nickase compositions.
Merck received its first US patent in February 2019 for its proxy-CRISPR technology, which makes CRISPR more efficient, flexible, and specific. The company has successfully out-licensed its CRISPR patent portfolio and continues to license its entire CRISPR patent portfolio for all fields of use. Merck is proactively and aggressively pursuing CRISPR patent out-licensing partners for therapeutics, agriculture, and research and welcomes such collaboration opportunities.
CRISPR technology is a core competency for Merck, which has 16 years’ experience with genome editing, spanning from discovery to manufacturing. The company develops technologies in a range of genome-editing applications, including gene knockout, gene integration, and CRISPR libraries for genetic screens, among others.