Pakistan made portable RAD ventilator gets US patent

Aga Khan University’s low-cost RAD to be launched after a year of trials

The portable and compact RAD ventilator developed at the Aga Khan University has received a US patent Image Aga Khan University
The portable and compact RAD ventilator developed at the Aga Khan University has received a US patent Image Aga Khan University

A low-cost, portable, briefcase-sized ventilator developed by Pakistani doctors, biomedical engineers, and software developers at Aga Khan University has received a US patent. A press release from the university in Karachi, Pakistan, dated 1 September 2021, states that the United States Patent and Trademark Office patent recognizes over 20 innovative aspects of the University’s Resuscitation Automation Device RAD. Moreover, the compact RAD can offer prompt, lifesaving treatment for patients suffering from critical respiratory problems.

People with severe forms of pneumonia or chronic obstructive pulmonary disease – two of the top ten leading causes of death in Pakistan – require immediate access to ventilators but the cost and size of existing ventilators mean they are only available in hospitals. “Patients facing breathing difficulties continue to face delays in receiving care due to two deficits in the clinical environment,” said Saleem Sayani, director of the Technology Innovation Support Centre and Digital Health Resource Centre at AKU. “There is a shortage of trained personnel who can effectively operate manually pumped ambu bags for moderately ill patients, and there is also a lack of high-end ventilators for critically ill patients.”

The RAD aims to act as a bridge between manually operated ambu bags – which can be difficult, unreliable, and distressing to use – and expensive ventilators with long waiting times. The patented device consists of a battery-operated motor that automatically inflates and deflates a medical-grade ambu bag in line with a self-adjusting, proprietary algorithm that ensures a stable air supply to patients suffering from breathing difficulties.

Since the RAD is compact enough to fit in an ambulance, moderately ill patients can also potentially access care while going to the hospital. Critically ill patients can also be put on the RAD while they wait for a ventilator to become available.

In addition, the RAD can be remotely operated through a mobile application which means that emergency room physicians can manage the device’s settings from afar while the patient is in the ambulance to ensure that s/he reaches the hospital in a stable condition. The app also gives hospital staff access to real-time patient health data before they arrive at the emergency room, enabling prompter care.

“Too many precious lives are lost due to lack of timely ventilation. Many ventilators are too complex to operate, too expensive and need a significant power source when available. Patients with infections, head injury, drug overdose, heart conditions all have medical emergencies where lives can be saved, especially at frontline healthcare facilities and during transport,” added Dr Junaid Razzak, director of AKU’s Center of Excellence for Trauma and Emergencies at AKU.

“The use of low-cost mobile ventilators in ambulances coupled with remote monitoring from the hospital through mobile technologies has the potential to significantly improve patient outcomes and increase chances of survival, particularly in low-resource countries like Pakistan,” commented Asad Latif, chair, Department of Anaesthesiology, AKU.

The idea for a portable, automated ventilator was initially pitched at AKU’s inaugural medical hackathon in August 2016. Dr Huba Atiq, assistant director at AKU’s Centre of Excellence for Trauma and Emergencies, was part of the team that proposed the idea.

Speaking about the inspiration for the RAD, she said, “In Pakistan, critically ill patients present late to healthcare facilities due to a lack of proper healthcare infrastructure. Even if they manage to reach the tertiary care facility after traveling a huge distance, the underdeveloped critical care process, lack of trained healthcare staff and resources, especially mechanical ventilators, results in an increased rate of critical care mortality. The invention of a low-cost, operator-friendly, mechanical ventilator represents a solution to bridge this gap and provide timely appropriate critical care services.”

RAD patent AKU
RAD portable ventilator developed at Agha Khan University in Karachi gets US Patent Photo AKU via Internet

Clinical trials of the RAD are to begin soon to assess its safety and efficacy among patients with respiratory problems. Early tests show that the device can provide a regular supply of oxygen to stabilize the health of a patient mannequin. The team anticipates the RAD to be launched a year after the completion of clinical trials.

The clinical trial objectives are in line with global efforts under the UN Sustainable Development Goal 3 to reduce premature mortality from communicable diseases such as pneumonia and non-communicable diseases such as asthma and COPD.


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